On September 25, 2015, ABC renewed Mistresses for a fourth season of 13 episodes. The season premiered on June 18, 2015, with a special two-hour premiere in a new Thursday timeslot.

On September 30, 2014, ABC renewed the series for a third season with production of the program being moved from Los Angeles to Vancouver, British Columbia. On September 25, 2013, ABC renewed Mistresses for a second season, which aired from June 2 to September 1, 2014. The Lifetime version was also to have starred Aytes, alongside Milano's Charmed co-star Holly Marie Combs. In 2008, Lifetime announced it was developing the series, but it never made it to air. This is the second attempt by a network to import the British series to the U.S. Steinberg wrote the pilot episode, which had previously been under consideration for a pilot order for ABC's fall 2012 schedule. In February 2012, ABC announced that it had green-lighted Mistresses with a direct-to-series order and a planned summer 2013 airdate.

Tabrett Bethell as Kate Davis (guest, season 2 main, season 4), Harry's sister who relocates to Los Angeles looking for love after the breakdown of her engagement.

Jennifer Esposito as Calista Raines (born Carla Rizzotti) (season 3), creative director of a luxury fashion brand who befriends Joss.

Rob Mayes as Marc Nickleby (seasons 3–4), a handsome new friend and colleague of Harry's and the uncle of Paul and Miranda's son who moves in with April.

Jason George as Dominic Taylor (main, seasons 1–2 guest, seasons 3–4), a lawyer and coworker of Savi's.

Erik Stocklin as Sam Grey (season 1), the son of Karen's deceased lover.

Brett Tucker as Harry Davis, a chef/restaurateur who is Savi's ex-husband.

Jes Macallan as Josslyn 'Joss' Carver, a real estate agent and the younger half-sister of Savi.

Rochelle Aytes as April Malloy, a widowed single mother, who is the owner of home furnishings boutique and cafe.

Karen Kim, a psychiatrist who was romantically involved with one of her patients.

Alyssa Milano as Savannah 'Savi' Davis (seasons 1–2), a lawyer who is Harry's ex-wife and the older half-sister of Joss.It had been expected that if there had been a fifth season it would have been intended to be the final season. On September 9, 2016, ABC canceled Mistresses after four seasons. However, ABC announced that Mistresses would premiere on June 3, 2013. The series was originally set to premiere on May 27, 2013. Steinberg, and stars Alyssa Milano, Rochelle Aytes, Yunjin Kim, Jes Macallan, and Jennifer Esposito in the lead roles. series of the same name, about the lives of four female friends and their involvement in an array of illicit and complex relationships. Mistresses is an American mystery drama soap opera television series based on the 2008–10 U.K.

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